The ColoCare Study

Faculty involved: Adetunji Toriola, Graham Colditz

ColoCare Team

The ColoCare Study follows a cohort of men and women who have been newly diagnosed with colorectal cancer (stages I-IV) and ascertains biological specimens and other data at repeated timepoints after diagnosis. This project will investigate molecular markers of response, and toxicity to treatment, recurrence and survival, as well issues related to quality of life.

The ColoCare Consortium was formed in 2007 at the Fred Hutchinson Cancer Research Center in 2007. Since then, several additional siges have joined: Fred Hutchinson Cancer Research Center; German Cancer Research Center; Huntsman Cancer Institute; Moffitt Cancer Center; The University of Tennessee Health Science Center; and Washington University School of Medicine.

For more information, visit The ColoCare Study’s website.

Select Publications:

Ulrich CM, Rankin C, Toriola AT, Makar KW, Altug-Teber O, … & Lenz HJ. Polymorphisms in folate-metabolizing enzymes and response to 5-fluorouracil among patients with stage II or III rectal cancer (INT-0144; SWOG 9304). Cancer. 2014 Nov 1;120(21):3329-3337. doi: 10.1002/cncr.28830. Epub 2014 Jul 15.

Toriola AT, Nguyen N, Scheitler-Ring K, & Colditz GA. Circulating 25-hydroxyvitamin D levels and prognosis among cancer patients: a systematic review. Cancer Epidemiol Biomarkers Prev. 2014 Jun;23(6):917-33. doi: 10.1158/1055-9965.EPI-14-0053. Epub 2014 Apr 1.

Kraus S, Hummler S, Toriola AT, Poole EM, Scherer D, … & Ulrich CM. Impact of genetic polymorphisms on adenoma recurrence and toxicity in a COX2 inhibitor (celecoxib) trial: results from a pilot study. Pharmacogenet Genomics. 2013 Aug;23(8):428-437. doi: 10.1097/FPC.0b013e3283631784.

Toriola AT, Cheng TY, Neuhouser ML, Wener MH, Zheng Y, Brown E, Miller JW,
Song X, Beresford SA, Gunter MJ, Caudill MA, & Ulrich CM. Biomarkers of
inflammation are associated with colorectal cancer risk in women but are not
suitable as early detection markers. Int J Cancer. 2013 Jun 1;132(11):2648-58.
doi: 10.1002/ijc.27942. Epub 2012 Dec 5. PubMed PMID: 23161620; PubMed Central
PMCID: PMC3609926.

Ulrich CM, Toriola AT, Siegel EM, Brenner H, Chang-Claude J, … & Grady W. Plasma 25-hydroxyvitamin D3, folate and vitamin B12 biomarkers among international colorectal cancer patients: a pilot study. J Nutr Sci. 2013 Apr 9;2:e9. doi: 10.1017/jns.2012.28. eCollection 2013.