Phase I Adaptive Design
- Bayesian Optimal Interval (BOIN), Continual reassessment method (CRM), Bayesian toxicity and efficacy monitoring: https://www.trialdesign.org/
- Toxicity probability interval: https://biostatistics.mdanderson.org/SoftwareDownload/SingleSoftware/Index/72
- R package for modified toxicity probability interval: https://cran.r-project.org/web/packages/TEQR/TEQR.pdf
- R package for phase I/II adaptive dose-finding for combination studies: https://cran.r-project.org/web/packages/dfcomb/
Phase II Trial Design (Simon’s 2-stage design)
http://cancer.unc.edu/biostatistics/program/ivanova/SimonsTwoStageDesign.aspx
Sequential Toxicity Monitoring (Continuous monitoring for toxicity using Pocock-type boundary)
http://cancer.unc.edu/biostatistics/program/ivanova/ContinuosMonitoringForToxicity.aspx
Sample Size Calculator
- Survival analysis: http://www.sample-size.net/sample-size-survival-analysis/
- Logistic regression main effect and interaction effect: https://www.dartmouth.edu/~eugened/power-samplesize.php
- Two independent group mean difference: http://www.sample-size.net/sample-size-means/
- Paired t-test: http://www.sample-size.net/sample-size-study-paired-t-test/