Faculty involved: Graham Colditz, Aimee James, Erin Linnenbringer, Mary Politi, Siobhan Sutcliffe
The partnership between The Southern Illinois University School of Medicine and Siteman Cancer Center investigates rural cancer disparities and ways to help educate, train, and implement effective strategies to reduce the disparities seen in rural communities.
Faculty Involved: Erika Waters, Jean Hunleth
Drs. Waters, Hunleth, and colleagues will used a mixed methods research design to gain in-depth understanding of the psychological and social factors that shape the decision making process that caregivers use to care for their asthmatic children. This project will provide evidence-based behavioral strategies to improve the lives of 6.2 million children who are affected by asthma.
Faculty involved: Erika Waters, PhD, MPH
This study, Communicating Multiple Disease Risks: A Translation of Risk Prediction Science, translates epidemiological data about five major health consequences of insufficient physical activity into a visual display that conveys individualized risk estimates in a way that is understandable and meaningful to diverse lay audiences and motivates physical activity behavior.
Faculty involved: Mary Politi, Bettina Drake, Esther Lu, Aimee James, Jean Hunleth, Erika Waters, PhD, MPH, Vetta Sanders Thompson, Graham Colditz
This line of research strives to engage all members of the community throughout the research process to help navigate the healthcare process.
Faculty involved: Yin Cao
Dr. Yin Cao received a Young Investigator Award from the National Comprehensive Cancer Network. This two-year award will support Dr. Cao in her work addressing colorectal cancer survival disparities among patients diagnosed under age 50 through integrating patients, treatment, and tumor molecular characteristics.
Faculty involved: Yin Cao
About 11% of colon cancers (CRC) and 18% of rectal cancers occur in adults younger than 50 years. In contrast to the recent population decline in CRC incidence in adults aged 50 and above, CRC incidence has increased in all 5-year age groups between 20 and 49 years. The majority of young-onset CRCs are diagnosed symptomatically with more advanced tumors. Dr. Cao is leading research to discover the genomic landscape of young-onset CRCs and the underlying lifestyle factors that may drive the rising incidence.
Faculty involved: Erin Linnenbringer
This four-year project examines existing data to investigate potential interplay among state-level inequalities (defined by race and/or gender), individual-level health behaviors, and genomic markers associated with estrogen receptor negative (ER-) breast cancer.
Faculty involved: Siobhan Sutcliffe, Aimee James
The MAPP study is a cohort study of patients with interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) from six sites across the United States. It was designed to better understand the natural history of these conditions and their underlying causes, taking a “whole-body” rather than a bladder- or prostate-specific approach.
Faculty involved: Mary Politi
This project will develop a preference-sensitive decision support tool for patients considering breast reconstruction after mastectomy. The tool will provide patient education, elicit patients’ preferences, and include personalized risk prediction to aid in the decision making process.
Faculty involved: Vetta Thompson Sanders
The St. Louis Patient Research Advisory Board was founded by and consists of CRFT program alumni who have completed a 15-week training program on research methods and are certified to conduct research with human subjects by the Human Research Protections Office at the Washington University School of Medicine. The PRAB is designed to help investigators with community-engaged or community-based research proposals/projects by having community members review proposals and give feedback.
Faculty involved: Aimee James, Siobhan Sutcliffe
The PLUS Research Network is a multi-site network designed to develop the evidence base for future clinical trials to prevent the development and progression of lower urinary tract symptoms in women and girls. Current projects include a qualitative focus group study, the development of new instruments to measure bladder health, systematic reviews of the literature, and analyses of existing study data to better understand bladder health and factors that contribute to the development and progression of lower urinary tract symptoms.
Faculty involved: Aimee James, Graham Colditz, Vetta Sanders Thompson, Bettina Drake, Esther Lu, Jean Hunleth
Community-based participatory research (CBPR) helps give community members voice in academic research. These projects evaluated current and past CBPR projects to discovery future best practices.
Faculty involved: Graham Colditz, Aimee James, Bettina Drake, Vetta Sanders Thompson
The mission of Siteman Cancer Center’s Program for the Elimination of Cancer Disparities (PECaD) is to create a national model for eliminating local and regional disparities in cancer education, prevention and treatment. Through a community advisory committee and community partnerships, PECaD works with community representatives to find solutions that reduce disparities.
Faculty involved: Bettina Drake
The Prostate Cancer Biorepository Network (PCBN) is a Department of Defense (DOD)/ Congressionally Directed Medical Research Program (CDMRP) bioresource that provides tissue and other biospecimens to all prostate cancer investigators.
Faculty involved: Bettina Drake, Graham Colditz
The long-term goal of this collaboration between Dr. Drake and The St. Louis Mens Group Against Cancer is to be able to identify patients with increased risk for dying of prostate cancer while they are still treatable.
Faculty involved: Graham Colditz, Siobhan Sutcliffe, Bettina Drake
The PIE study is a cohort study of prostate cancer survivors who underwent prostate surgery at Washington University School of Medicine and Brigham & Women’s Hospital. These men were followed for one year after their surgery to better understand the natural history of treatment side effects, such as urinary incontinence and sexual dysfunction, and possible factors that influence the natural history of these side effects, such as physical activity and obesity.
Faculty involved: Adetunji Toriola, Graham Colditz, Rosy Luo
A very dense breast on mammogram is one of the strongest risk factors for breast cancer, and many women in the United States have extremely dense breasts. There is, however, very limited knowledge on how to modify breast density to reduce breast cancer risk
Faculty involved: Feng Gao, Esther Lu, Rosy Luo, Graham Colditz, Siobhan Sutcliffe, Yan Yan
The Siteman Biostatistics Shared Resource (SBSR) facility is a shared resource core supporting consultation on biostatistics and epidemiology. The facility supports cancer research through experimental designs, study monitoring and data analyses.
Faculty involved: Siobhan Sutcliffe
This project, the Department of Defense Serum Repository Study of the Influence of Infections on Biomarkers of Prostate Pathology, is nested within the large population of men on active U.S. military duty with stored blood samples in the Department of Defense Serum Repository. The project examines the short- and longer-term influence of genitourinary and non-genitourinary infections on biomarkers of prostate pathology to inform the possible influence of infections on later prostate cancer risk.
Faculty involved: Mary Politi, Aimee James, Esther Lu, Jean Hunleth
The goal of this grant from the American Cancer Society is to help cancer patients and survivors choose health insurance plans that best meet their health and financial needs. An existing decision support tool will be tailored based on patient interview data, and the modified tool will be evaluated with a 3-arm randomized trial.
Faculty involved: Aimee James
Nonadherence can have significant negative health effects for the individual and contribute to increases in hospitalization, healthcare costs, and mortality. Adherence is a complex issue, but cost and affordability of medication is a common and critical barrier.The short-term objective is to identify how patients and healthcare providers approach affordability and adherence and use those data to refine and pilot test an intervention promoting patient-provider discussion about cost, affordability, and adherence. The long- term objective is to deliver interventions to reduce cost-related nonadherence.
Faculty involved: Graham Colditz, Erika Waters, PhD, MPH, Adetunji Toriola, Bettina Drake, Siobhan Sutcliffe, Yikyung Park
Personalized health assessment tool that allows people to see their risk for common chronic conditions, such as diabetes, heart disease, stroke, and cancer risk.