Phase I Adaptive Design

Phase II Trial Design (Simon’s 2-stage design)

http://cancer.unc.edu/biostatistics/program/ivanova/SimonsTwoStageDesign.aspx

Sequential Toxicity Monitoring (Continuous monitoring for toxicity using Pocock-type boundary)

http://cancer.unc.edu/biostatistics/program/ivanova/ContinuosMonitoringForToxicity.aspx

Sample Size Calculator