Clues found to early lung transplant failure

Daniel KreiselDaniel Kreisel, MD, PhDResearchers at Washington University School of Medicine in St. Louis and Northwestern University Feinberg School of Medicine in Chicago have uncovered the precise cells that flow into and harm the lung soon after  lung transplants. The resulting dysfunction is the leading cause of early death after lung transplantation and contributes to organ rejection that can lead to death months or years later. The discovery, in mice, may lead to drug therapies that target the destructive cells.

Daniel Kreisel, MD, PhD, surgical director of lung transplantation at Washington University and Barnes-Jewish Hospital, is the study's senior author, and Hsi-Min “Jim” Hsiao, PhD, a staff scientist in Kreisel’s laboratory is the co-first author.

See Washington University School of Medicine press release on study.