Ying Liu, MD, PhD, MPH

Instructor, Division of Public Health Sciences
Department of surgery
liuyi@wudosis.wustl.edu
(314) 747-5601

Research Overview
Dr. Liu is an epidemiologist whose primary research interests are in the areas of breast cancer prevention and prognosis. Specifically, Dr. Liu’s current research involves (1) identifying early life factors (e.g., growth and developmental factors, dietary factors) in childhood and adolescence that are associated with risk of breast cancer and its intermediate risk markers, (2) identifying biomarkers expressed in epithelial and stromal cells that predict the prognosis of benign and premalignant breast diseases including DCIS and benign breast disease, and (3) characterizing the pathology of invasive breast cancer in women with a prior history of benign breast disease. Using the biological markers to optimize the AJCC staging system for predicting breast cancer prognosis is also part of Dr. Liu’s research focus. Dr. Liu is collaborating with pathologists to evaluate how histological and biological diversity within individual cases of benign and premalignant breast diseases including DCIS and columnar cell hyperplasia influences subsequent breast cancer risk. In addition, Dr. Liu participated in a longitudinal quality of life study in women with DCIS and early invasive breast cancer in which she evaluated patients’ perceived risk of recurrence and fear of recurrence and their relations to health behaviors and psychological outcomes.

Research Support
3380-80323A  (Liu, Y)                                        3/1/11 ―  6/31/12
BJH Foundation Cancer Frontier Fund
Characterization of the stroma from ductal carcinoma in situ and clinical outcome
The specific aim of this study is to evaluate a novel set of the proteins expressed in the DCIS-associated stroma in relation to the risk of invasive progression. 
Role: Principal Investigator 
 
3380-80323  (Colditz, GA)                                  3/1/11 ― 6/31/12
BJH Foundation Cancer Frontier Fund
Adolescent diet and risk of proliferative benign breast disease
This study is to investigate the relationship between adolescent alcohol and fiber consumption and the risk of proliferative benign breast disease.
Role: Co-Investigator

Recent Publications
Jeffe DB, Pérez M, Liu Y, Collins KK, Aft RL, Schootman M. Quality of life over time in women diagnosed with ductal carcinoma in situ, early-stage invasive breast cancer, and age-matched controls. Breast Cancer Res Treat 2012;134:379-391.

Liu Y, Tamimi RM, Berkey CS, Willett WC, Collins LC, Schnitt SJ, Connolly JL, Colditz GA. Intakes of alcohol and folate during adolescence and risk of proliferative benign breast disease. Pediatrics 2012;129:e1192-8.

Liu Y, Pérez M, Schootman M, Aft RL, Gillanders WE, Jeffe DB. Correlates of fear of cancer recurrence in women with ductal carcinoma in situ and early invasive breast cancer. Breast Cancer Res Treat 2011;130:165-73.

Collins KK, Fields RC, Baptiste D, Liu Y, Moley J, Jeffe DB. Racial differences in survival after surgical treatment for melanoma. Ann Surg Oncol 2011;18:2925-36.

Liu Y, Tamimi RM, Collins LC, Schnitt SJ, Gilmore HL, Connolly JL, Colditz GA. The association between vascular endothelial growth factor expression in invasive breast cancer and survival varies with intrinsic subtypes and use of adjuvant systemic therapy: Results from the Nurses’ Health Study. Breast Cancer Res Treat 2011;129:175-84.

Collins KK, Liu Y, Schootman M, Aft R, Yan Y, Dean G, Eilers M, Jeffe DB. Effects of breast cancer surgery and surgical side effects on body image over time. Breast Cancer Res Treat 2011;126:167-76.

Liu Y, Tamimi RM, Collins LC, Schnitt SJ, Gilmore HL, Connolly JL, Colditz GA. The association between vascular endothelial growth factor expression in invasive breast cancer and survival varies with intrinsic subtypes and use of adjuvant systemic therapy: Results from the Nurses’ Health Study. Breast Cancer Res Treat 2011;129:175-84.

Collins KK, Liu Y, Schootman M, Aft R, Yan Y, Dean G, Eilers M, Jeffe DB. Effects of breast cancer surgery and surgical side effects on body image over time. Breast Cancer Res Treat 2011;126:167-76.

Collins KK, Fields RC, Baptiste D, Liu Y, Moley J, Jeffe DB. Racial differences in survival after surgical treatment for melanoma. Ann Surg Oncol 2011 Apr 9. [Epub ahead of print]

Pérez M, Liu Y, Aft RL, Schootman M, Aft RL, Schechtman KB, Gillanders WE, Jeffe DB. Changes in sexual problems over time in women with and without early-stage breast cancer. Menopause 2010;17:924-937.

Liu Y, Pérez M, Schootman M, Aft RL, Gillanders WE, Ellis MJ, Jeffe DB. A longitudinal study of factors associated with perceived risk of recurrence in women with ductal carcinoma in situ and early-stage invasive breast cancer. Breast Cancer Res Treat 2010;124:835-44.

Liu Y, Pérez M, Aft RL, Massman K, Robinson E, Myles S, Schootman M, Gillanders WE, Jeffe DB. Accuracy of perceived risk of recurrence among patients with early-stage breast cancer. Cancer Epidemiol Biomarkers Prev 2010;19(3):675-80.

Bailey EH, Pérez M, Aft RL, Liu Y, Schootman M, Jeffe DB. Impact of multiple caregiving roles on depressed mood in early-stage breast cancer patients and same-age controls. Breast Cancer Res Treat 2010;121:709-18.

EDITORIAL RESPONSIBILITIES

  • Reviewer, Breast Cancer Research and Treatment, 2011-
  • Reviewer, Psycho-Oncology, 2011-
  • Reviewer, International Journal of Public Health, 2012-