Margaret Olsen, PhD, MPH

Research Associate Professor, Division of Infectious Diseases, Division of Public Health Sciences
Departments of Medicine and Surgery
molsen@dom.wustl.edu
(314) 454-8320

Research Overview
Dr. Olsen’s background is in clinical microbiology, epidemiology and biostatistics. Her primary appointment is in the Division of Infectious Diseases. Dr. Olsen’s primary interests include the epidemiology of hospital-acquired infections, particularly surgical site infections after breast cancer and spine surgery. More recently, she has become interested in using large administrative and claims datasets to study infectious and noninfectious complications of surgical procedures. The claims data offer advantages to these studies because of the large numbers of surgical procedures and infectious outcomes, and generalizability due to inclusion of procedures performed at multiple hospitals or ambulatory settings. Use of claims data for secondary analysis also entails many challenges, and Dr. Olsen is working to develop algorithms for researchers using these data to study complications after events (such as surgical procedures).

Dr. Olsen teaches a course in Infectious Disease Epidemiology in the Saint Louis University School of Public Health MPH program.

Grants
Current:
NIH R01CA149614-01; Olsen (PI)   2/01/2010 – 1/31/2015   
    
Immediate vs. Delayed Reconstruction and Breast Cancer Surgery Complications
The goals of this grant are to use longitudinal private health insurer claims data to determine the incidence and risk factors for surgical site infection and noninfectious wound complications after mastectomy and breast reconstruction.

AHRQ R01 HS019713; Olsen (PI)   09/30/2010-07/31/2013
Surgical Site and Clostridium difficile Infections after Ambulatory Surgery
The major goals of this grant are to determine the incidence of surgical site and Clostridium difficile infection after three common surgical procedures performed in ambulatory surgical centers and to identify risk factors and clinical and economic outcomes of these infections. We will use the patient-level risk factors to develop risk prediction indices that can be used to improve outcomes after these common surgical procedures.

NIH 3UL1RR024131S1; Johnston (PI)   1/08/2010-9/24/2011
Olsen (PI, sub-award) 
CELDAC:Comparative Effectiveness Large Dataset Analysis Core
The major goals of this subaward are to evaluate the claims data infrastructure through pilot studies on the comparative effectiveness of orthopedic surgery procedures. 

NIH 1R21 AR055755; Olsen (PI)   4/01/2009-3/31/2012    
Infectious Complications of Spine Surgery in the Elderly
The major goals of this grant are to use Medicare claims data for spine surgery to determine the incidence and clinical outcomes of surgical site infection and noninfectious wound complications, and to determine risk factors for these wound complications at the patient, surgeon and hospital levels.

AHRQ R24 H5019455; Fraser (PI)   08/01/2010-07/31/2012
Washington University Comparative Effectiveness Administrative Data Repository
The goals of this ARRA stimulus grant are to expand and enhance infrastructure and comparative effectiveness research using administrative data. The project will enhance existing resources and provide support for pilot projects and research. 
Role: Co-Investigator

CDC 1U54CK000162-01; Fraser (PI)   03/01/2011-02/28/2016         
Washington University and BJC Epi-Center for Prevention of Healthcare-Associated Infections
This Epicenter cooperative agreement will provide resources to develop and evaluate new methods to prevent hospital-acquired infections and antimicrobial resistance in U.S hospitals. Specifically, we are studying new approaches to reduce central line-associated blood stream infections, ventilator-associated pneumonia, Clostridium difficile and urinary tract infections.
Role: Co-Investigator

Selected Publications

  1. Huang SS, Placzek H, Livingston J, Ma A, Onufrak F, Dunn J, Kleinman D, Bratzler D, Olsen MA, et al. Use of Medicare claims to rank hospitals by surgical site infection (SSI) risk following coronary artery bypass graft surgery. Infect Control Hosp Epidemiol 2011;32:775-83.
  2. Marschall J, Bhavan KP, Olsen MA, Fraser VJ, Wright NM, Warren DK. The impact of prebiopsy antibiotics on pathogen recovery in hematogenous vertebral osteomyelitis. Clin Infect Dis 2011;52:867-72.
  3. Olsen MA, Butler AM, Willers DM, Gross GA, Hamilton BH, Fraser VJ. Comparison of costs of surgical site infection and endometritis after cesarean delivery using claims and medical record data. Infect Control Hosp Epidemiol 2010;31:872-5.
  4. Honda H, Krauss MJ, Jones JC, Brookmeyer PK, Olsen MA, Warren DK. Mortality associated with S. aureus bacteremia: the value of Infectious Diseases consultation. Am J Med 2010;123:631-7.
  5. Olsen MA, Fraser VJ.  ICD-9-CM diagnosis codes vs. wound cultures for the diagnosis of surgical site infection after mastectomy and breast reconstruction. Infect Control Hosp Epidemiol 2010;31:544-7.
  6. Olsen MA, Butler AM, Willers DM, Gross GA, Hamilton BH, Fraser VJ. Attributable costs of surgical site infection and endometritis after low transverse cesarean delivery. Infect Control Hosp Epidemiol 2010;31:276-82.
  7. Bhavan KP, Marschall J, Olsen MA, Fraser VJ, Wright NM, Warren DK. The epidemiology of hematogenous vertebral osteomyelitis: a cohort study in a tertiary care hospital. BMC Infect Dis 2010;Jun 7:10,158.
  8. Butler AM, Merz LR, Olsen MA, Woeltje KF, Camins BC, Guth RM, Fraser VJ. The attributable costs of Enterococcal bloodstream infections in a non-surgical hospital cohort. Infect Control Hosp Epidemiol 2010;31:28-35.
  9. Olsen MA, Butler AM, Willers DM, Gross GA, Devkota P, Fraser VJ. Risk factors for endometritis following cesarean section. Infect Control Hosp Epidemiol 2010;31:69-77.
  10. Olsen MA, Higham-Kessler J, Yokoe DS, Butler AM, Stevenson KB, Vostok J, Khan Y, Fraser VJ. Development of a risk stratification index for surgical site infection after abdominal hysterectomy. Infect Control Hosp Epidemiol 2009;30:1077-83.
  11. Bolon MK, Hooper D, Stevenson KB, Greenbaum M, Olsen MA, Herwaldt L, Noskin GA, Fraser VJ, Climo M, Khan Y, Vostok J, Yokoe DS. Improved surveillance for surgical site infection following orthopedic implant procedures: extending applications for automated data. Clin Infect Dis 2009;48:1223-9.
  12. Olsen MA, Lefta M, Dietz JR, Brandt KE, Aft R, Matthews R, Mayfield J, Fraser VF.  Risk factors for surgical site infection after major breast surgery. J Am Coll Surg 2008;207:326-35.
  13. Olsen MA, Butler AM, Willers DM, Devkota P, Gross GA, Fraser VJ.  Risk factors for surgical site infection following low transverse cesarean section. Infect Control Hosp Epidemiol 2008;29:477-84.
  14. Dubberke ER, Butler AM, Reske KA, Agniel D, Olsen MA, D’Angelo G, McDonald LC, Fraser VJ.  Attributable outcomes of endemic Clostridium difficile-associated disease in non-surgical patients. Emerg Inf Dis 2008;14:1031-8.
  15. Dubberke ER, Reske KA, Olsen MA, McDonald LC, Fraser VJ.  Short and long-term attributable cost of Clostridium difficile-associated disease in non-surgical patients. Clin Inf Dis 2008;46:497-504.

Pub Med for Margaret A. Olsen, PhD, MPH